Figure 5 | Scientific Reports

Figure 5

From: The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment

Figure 5

Treatment with novel adamantane derivatives (2, 3) or drugs—vildagliptin and saxagliptin, attenuates memory impairment in induced diabetic mice in passive avoidance test (PA). Retention test was performed after 1 h (A) and 24 h (B) after the end of the training stage. The bars illustrate the latency to enter the dark compartment of apparatus in testing stage for experimental groups—CTL non-diabetic mice, DM diabetic mice, DM-Vil vildagliptin-treated mice [20 mg/kg, po], DM-Sax saxagliptin-treated mice [10 mg/kg, po], DM-compound 2 compound 2-treated mice [50 mg/kg, po], DM-compound 3 compound 3-treated mice [50 mg/kg, po], respectively. Each column represent means ± SD (n = 8). Repeated-measures ANOVA, followed by Tukey's post hoc test was used. (A-B) *p < 0.05 ; **p < 0.01 compared with healthy control group. (A,B) #p < 0.05; ##p < 0.01 compared with diabetic mice group.

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