Figure 1

Summary figure showing within- and cross-network sFC and dFC variability abnormalities in chronic low back-related leg pain. Two-sample t test, P < 0.05, FDR correction. Note: The within- and cross-network abnormalities in the typical and five specific frequency bands are shown as a table in the figure. The right panel shows the legend for the dynamic pain connectome. Green indicates the salience network, blue indicates the descending antinociceptive pathway, and red indicates the ascending nociceptive pathway. Both static and dynamic functional connectivity variability are depicted in the figure. Solid lines indicate hyperconnectivity, and dotted lines indicate hypoconnectivity between networks. sFC static functional connectivity, DMN default mode network, SN salience network, Asc ascending nociceptive pathway.