Figure 7 | Scientific Reports

Figure 7

From: Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment

Figure 7

Cellular localization and outcome of differentially abundant proteins associated with DNA damage and repair pathways. Proteins with differential abundance (|FC|≥ 3) in blood plasma 24 h after 0.5 Gy total body irradiation were enriched with Gene Ontology terms for DNA damage and repair processes. Cellular localization according to UniProt (please note different cellular localizations for certain proteins.) Functional outcome inferred from Gene Ontology terms and protein function according to UniProt. (See SI Appendix, Table S8 for further details on functions, interactions, and references.) Panels (A–F) illustrate protein functions and outcomes for each investigated group (see respective header). Green oval, protein is overabundant; red oval, protein is underabundant; note fold change is visualized by color intensity. Blue rectangles, activation of cellular function/outcome; yellow rectangle, inhibition of cellular function/outcome. 7w, 7-weeks-old (juveniles); 18w, 18-weeks-old (adults); ♀, female; ♂, male. Please note that presented data is normalized to respective unirradiated control groups. Drawings were produced with Microsoft PowerPoint v16.0.4266.1001 and Adobe Photoshop CS5 Portable v12.0.

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