Figure 6

Correlation between epiallele classes and epiallele distribution with mRNA expression levels of Fxyd1a in brain and heart. (a) The graph reports r values derived from Pearson correlation between epiallele classes and mRNA expression of Fxyd1a, regardless of developmental time points. (b) Heatmaps of r values derived from Pearson correlation between epialleles and mRNA expression of Fxyd1a in brain and heart. Epialleles are shown as a string of numbers where 1 indicates methylated CpG sites and 0 indicates non-methylated CpG sites. The numbers of the strings correspond to the CpG sites analyzed in the Fxyd1a amplicon (shown in Fig. 2a) in the following order: − 118, − 91, − 47, − 3, + 92, + 112, + 131. The scale color from blue to red indicates a positive to negative correlation (− 1 ≤ r ≤ 1), respectively. Statistical analyses were performed using a Pearson correlation test (*p ≤ 0.05; **p ≤ 0.01).