Figure 11
From: Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia
The putative role of Tmem174 in the control of plasma Pi levels. Tmem174 interacts with NaPi2a and is involved in internalization by PTH and FGF23. Under a high Pi load, urinary Pi excretion is enhanced by the internalization of NaPi2a induced by PTH and FGF23, and hyperphosphatemia is prevented. In Tmem174-KO mice, internalization of NaPi2a is resistant to PTH and FGF23. As a result, Pi reabsorption is maintained, and plasma Pi concentration increases. Tmem174 is expected to be a molecule that is associated with both the induction of phosphaturic hormones (PTH, FGF23) and the regulation of NaPi2a in the proximal tubules. G glomerulus, PT proximal tubule.
