Table 3 Biomarker results (mean ± SD).

From: A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers

Variables

Control n = 66

Post MI n = 66

p value

HbA1c (mmol/l)

39.25 ± 8.29

45.27 ± 16.89

0.053

Sodium (mmol/l)

140.28 ± 1.77

138.95 ± 2.52

0.001

Potassium (mmol/l)

4.40 ± 0.31

4.33 ± 0.36

0.401

Urea (mmol/l)

5.38 ± 1.18

5.47 ± 2.18

0.541

Creatinine (µmol/l)

79.28 ± 16.66

84.05 ± 22.21

0.272

Creatinine clearance (ml/min)

110 ± 42.42

104.80 ± 34.93

0.733

HGB (g/l)

146.38 ± 11.00

142.39 ± 15.44

0.095

Haematocrit (l/l)

0.43 ± 0.03

0.42 ± 0.04

0.145

White cell count (109 µl/l)

6.76 ± 1.73

8.90 ± 3.01

0.001

Platelet count (109/l)

263.17 ± 46.54

262.59 ± 68.75

0.426

MCV (fl)

88.93 ± 4.30

88.20 ± 5.93

0.438

CRP (mg/l)

3.24 ± 6.39

20.96 ± 42.49

0.001

NT-proBNP (ng/l)

74.70 ± 186.68

1049.11 ± 1663.65

0.001

Total cholesterol (mmol/l)

5.11 ± 0.89

4.65 ± 1.44

0.005

Triglyceride (mmol/l)

1.67 ± 0.96

1.97 ± 1.35

0.217

HDL (mmol/l)

1.48 ± 0.48

1.13 ± 0.30

0.001

LDL (mmol/l)

2.85 ± 0.72

2.69 ± 1.33

0.124

Non-HDL (mmol/l)

3.62 ± 0.97

3.52 ± 1.41

0.404

Chol-HDL ratio

3.79 ± 1.37

4.31 ± 1.58

0.048

Prothrombin Time (s)

10.52 ± 0.50

10.94 ± 0.70

0.001

APTT (s)

26.47 ± 2.19

35.17 ± 29.28

0.468

Fibrinogen (g/l)

3.12 ± 0.61

3.89 ± 1.05

0.001

Urate (mmol/l)

0.32 ± 0.07

0.35 ± 0.11

0.280

Apolipoprotein A (g/l)

1.54 ± 0.29

1.34 ± 0.25

0.001

Apolipoprotein B (g/l)

1.02 ± 0.23

1.04 ± 0.31

0.949

Folate (nmol/l)

8.23 ± 6.06

6.45 ± 4.15

0.088

Homocysteine (µmol/l)

14.35 ± 6.96

15.81 ± 7.15

0.084

Vitamin B12 (pmol/l)

436.97 ± 210.39

396.92 ± 174.68

0.348

Adiponectin (µg/ml)

11.15 ± 6.20

8.58 ± 5.92

0.001

H-FABP (ng/ml)

3.62 ± 2.04

13.75 ± 29.73

0.001

HDL-3 (mg/dl)

20.17 ± 4.51

17.73 ± 4.75

0.001

Serum IL-1α (pg/ml)

0.48 ± 0.13

0.47 ± 0.13

0.320

Serum IL-1β (pg/ml)

2.38 ± 2.77

1.98 ± 0.50

0.550

Serum IL-2 (pg/ml)

4.25 ± 5.62

3.46 ± 1.37

0.673

Serum IL-4 (pg/ml)

2.80 ± 1.77

2.43 ± 0.47

0.332

Serum IL-6 (pg/ml)

1.92 ± 2.36

8.17 ± 16.77

0.001

Serum IL-8 (pg/ml)

10.87 ± 8.40

13.37 ± 13.56

0.082

Serum IL-10 (pg/ml)

1.38 ± 0.71

1.39 ± 0.46

0.469

Serum MCP-1 (pg/ml)

236.54 ± 100.32

201.79 ± 124.48

0.006

Serum TNF-α (pg/ml)

2.96 ± 2.17

2.75 ± 0.87

0.594

Serum VEGF (pg/ml)

120.62 ± 102.64

162.15 ± 123.21

0.043

Serum IFNɣ (pg/ml)

0.69 ± 0.67

0.98 ± 2.91

0.523

Serum EGF (pg/ml)

80.79 ± 41.54

60.89 ± 38.96

0.011

Plasma IL-1α (pg/ml)

0.44 ± 0.14

0.43 ± 0.13

0.796

Plasma 1L-1β (pg/ml)

2.42 ± 4.35

1.83 ± 0.52

0.366

Plasma IL-2 (pg/ml)

4.03 ± 5.23

3.31 ± 1.08

0.982

Plasma IL-4 (pg/ml)

2.82 ± 1.81

2.30 ± 0.49

0.031

Plasma IL-6 (pg/ml)

1.99 ± 3.00

7.06 ± 10.88

0.001

Plasma IL-8 (pg/ml)

4.74 ± 4.04

5.20 ± 8.14

0.564

Plasma IL-10 (pg/ml)

1.29 ± 0.46

1.43 ± 0.52

0.094

Plasma MCP-1 (pg/ml)

90.41 ± 37.16

87.13 ± 70.29

0.103

Plasma TNF-α (pg/ml)

2.95 ± 5.48

2.33 ± 0.87

0.347

Plasma VEGF (pg/ml)

24.92 ± 21.48

20.22 ± 9.97

0.468

Plasma IFNɣ (pg/ml)

0.63 ± 0.57

1.04 ± 2.88

0.478

Plasma EGF (pg/ml)

21.09 ± 16.39

16.04 ± 15.29

0.060

ADMA (µmol/l)

3.15 ± 1.68

3.63 ± 11.93

0.258

LRG-1 (µg/ml)

14.79 ± 9.44

11.93 ± 4.92

0.048

  1. HbA1c glycated haemoglobin, HGB haemoglobin, MCV corpuscular volume, HDL high-density lipoprotein, LDL low-density lipoprotein, Chol-HDL cholesterol-high-density lipoprotein, NT-proBNP N-terminal pro brain natriuretic peptide, H-FABP heart-type fatty acid-binding protein, CRP C-reactive protein, IL interleukin, MCP-1 monocyte chemoattractant protein-1, VEGF vascular endothelial growth factor, TNF-α tumour necrosis factor alpha, IFNɣ interferon gamma, EGF endothelial growth factor, ADMA asymmetrical dimethylarginine, LRG-1 leucine-rich alpha-2-glycoprotein-1.
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