Table 4 Multivariate logistic regression with biomarkers and ocular parameters for detecting CAD.

Biomarkers/ocular parameters	AUROC	Sensitivity %	Specificity %	PPV%	NPV%
Log₁₀ NT-proBNP, adiponectin, log₁₀ H-FABP, Va	0.977	94.7	91.5	91.5	94.7
Log₁₀ NT-proBNP, log₁₀ adiponectin, log₁₀ H-FABP, Vs	0.976	93.0	93.2	93.0	93.2
Log₁₀ NT-proBNP, log₁₀ adiponectin, Vs	0.967	93.0	91.5	91.4	93.1
Log₁₀ NT-proBNP, log₁₀ adiponectin, Va	0.966	94.7	93.2	93.1	94.8
Log₁₀ H-FABP, log₁₀ NT-proBNP, Va	0.953	88.1	91.9	91.2	89.1
Log₁₀ H-FABP, log₁₀ NT-proBNP, Vs	0.953	86.4	90.3	89.5	87.5
Log₁₀ H-FABP, log₁₀ NT-proBNP, log₁₀ WSR	0.936	84.7	88.7	87.7	85.9
Log₁₀ NT-proBNP, Vs	0.926	85.0	83.9	83.6	85.2
Log₁₀ NT-proBNP, Va	0.925	83.3	85.5	84.7	84.1
IL-6, Vs	0.840	76.2	76.2	76.2	76.2
Log₁₀ H-FABP, Vs	0.830	73.0	76.6	75.4	74.2
Log₁₀ H-FABP, Va	0.815	73.0	71.9	71.9	73.0
CRP, D	0.810	79.4	67.2	71.4	75.9
Log₁₀ adiponectin, log₁₀ WSR	0.769	76.3	60.3	66.2	71.4
Log₁₀ adiponectin, Va	0.721	76.2	53.1	61.5	69.4
Log₁₀ adiponectin, D	0.702	72.1	54.2	62.0	65.3
Vs	0.706	63.1	73.4	70.7	66.2
Log₁₀ adiponectin	0.674	65.6	62.5	63.6	64.5
Log₁₀ NT-proBNP	0.897	78.7	90.6	88.9	81.7
QRISK3 score	0.732	71.7	64.9	68.3	68.5
Age (years)	0.604	59.1	57.6	58.2	58.5

Significant values are in bold.
CRP C-reactive protein, H-FABP heart-type fatty acid-binding protein, IL-6 interleukin-6, NT-proBNP N-terminal pro brain natriuretic peptide, D vessel diameter, Va axial velocity, Vs cross-sectional velocity, WSR wall shear rate, AUROC area under receiver operator characteristic curve, PPV positive predictive value, NPV negative predictive value.

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