Table 1 Baseline characteristics for patients with MPV/PC > 0.036 versus MPV/PC ≤ 0.036 in primary and validation cohort.

Clinical parameter	Primary cohort				Validation cohort
Clinical parameter	MPV/PC > 0.036 (n = 246)	MPV/PC ≤ 0.036 (n = 250)	χ²	P	MPV/PC > 0.036 (n = 107)	MPV/PC ≤ 0.036 (n = 72)	χ²	P
Sex			0.63	0.427			10.23	0.001*
Male	161	172			71	63
Female	85	78			36	9
Age			3.83	0.050			2.43	0.119
≤ 60	158	181			62	50
> 60	88	69			45	22
Tumor location			0.328	0.849			2.67	0.263
Upper	45	43			16	5
Middle	96	94			37	27
Lower	105	113			54	40
Histological grade			0.12	0.729			0.039	0.843
Well or moderately differentiated	115	113			64	42
Poorly or not differentiated	131	137			43	30
Lauren type			1.47	0.479			1.30	0.521
Diffuse	41	36			19	16
Intestinal	106	121			49	27
Mixed	99	93			39	29
Tumor size			19.53	< 0.001*			9.43	0.002*
≤ 5	130	83			56	21
> 5	116	167			51	51
Lymphovascular invasion			0.51	0.476			0.11	0.741
No	174	184			68	44
Yes	72	66			39	28
Perineural invasion			0.88	0.348			0.18	0.671
No	148	140			76	49
Yes	98	110			31	23
TNM stage (AJCC, 8th)			35.21	< 0.001*			6.34	0.042*
I	86	32			36	12
II	70	81			49	42
III	90	137			22	18
Adjuvant chemotherapy			2.91	0.088			0.09	0.765
No	107	90			41	26
Yes	139	160			66	46
NLR			27.113	< 0.001*			32.01	< 0.001*
NLR ≤ 1.35	150	94			50	5
NLR > 1.35	96	156			57	67
PLR			21.424	< 0.001*			12.23	< 0.001*
PLR ≤ 132	113	65			70	28
PLR > 132	133	185			37	44
SII			25.77	< 0.001*			32.30	< 0.001*
SII ≤ 315	164	110			80	23
SII > 315	82	140			27	49
CNPS			36.62	< 0.001*			29.03	< 0.001*
0	90	38			44	5
1	83	83			32	23
2	73	129			31	44

TNM tumor, node, metastasis, AJCC American Joint Committee on Cancer, MPV/PC mean platelet volume to platelet count, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, CNPS combined neutrophil-platelet score, SII systemic immune-inflammation index. *Represents a statistically difference.

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