Table 1 Characteristics and distribution of oropharyngeal cancer patients by clinical and demographic factors.
From: Genetic susceptibility to patient-reported xerostomia among long-term oropharyngeal cancer survivors
Variables | All patients (N = 359) | Xerostomia information missing (N = 7) | None to mild xerostomia (N = 214) | Moderate to severe xerostomia (N = 138) |
|---|---|---|---|---|
Age at diagnosis, y, median (range, IQR) | 55 (34–80, 50–60) | 55 (34–73, 50–61) | ||
Survival time, y, median (range, IQR) | 8 (2–16, 6–11) | 8 (3–15, 5–11) | ||
Radiation dose, Gy, median (range, IQR) | 66 (60–72, 66–70) | 70 (40–72.6, 66–70) | ||
Sex, No. (%) | ||||
Female | 51 (14.2) | 0 | 24 (47.1) | 27 (52.9) |
Male | 308 (85.8) | 7 | 190 (63.1) | 111 (36.9) |
Education, No. (%) | ||||
> Highschool | 272 (75.8) | 6 | 170 (63.9) | 96 (36.1) |
≤ Highschool | 59 (16.4) | 0 | 27 (45.8) | 32 (54.2) |
Missing | 28 (7.8) | 1 | 17 (63.0) | 10 (37.0) |
Race/ethnicity, No. (%) | ||||
Non-Hispanic white | 348 (97.0) | 7 | 209 (61.3) | 132 (38.7) |
Non-Hispanic black | 1 (0.3) | 0 | 0 (0.0) | 1 (100.0) |
Hispanic | 3 (0.8) | 0 | 2 (66.7) | 1 (33.3) |
Missing | 7 (1.9) | 0 | 3 (42.9) | 4 (57.1) |
Primary site, No. (%) | ||||
Tonsil | 157 (43.7) | 2 | 96 (61.9) | 59 (38.1) |
Base of tongue, GPS | 189 (52.7) | 5 | 110 (59.8) | 74 (40.2) |
Other | 13 (3.6) | 0 | 8 (61.5) | 5 (38.5) |
T classification, No. (%) | ||||
1 | 125 (34.8) | 3 | 79 (64.8) | 43 (35.2) |
2 | 136 (37.9) | 3 | 80 (60.2) | 53 (39.8) |
3 | 61 (17.0) | 0 | 34 (55.7) | 27 (44.3) |
4 | 37 (10.3) | 1 | 21 (58.3) | 15 (41.7) |
N classification, No. (%) | ||||
N0 | 38 (10.6) | 2 | 21 (58.3) | 15 (41.7) |
N1 + 2a | 92 (25.6) | 3 | 62 (69.7) | 27 (30.3) |
2b + 3 | 175 (48.8) | 2 | 100 (57.8) | 73 (42.2) |
2c | 54 (15.0) | 0 | 31 (57.4) | 23 (42.6) |
HPV status, No. (%) | ||||
Negative | 26 (7.2) | 0 | 15 (57.7) | 11 (42.3) |
Positive | 124 (34.5) | 1 | 75 (61.0) | 48 (39.0) |
Unknown | 209 (58.2) | 6 | 124 (61.1) | 79 (38.9) |
Cigarette smoking, No. (%) | ||||
Never | 162 (45.1) | 2 | 101 (63.1) | 59 (36.9) |
Former smoker at time of diagnosis | 149 (41.5) | 5 | 89 (61.8) | 55 (38.2) |
Quit smoking subsequent to diagnosis | 35 (9.8) | 0 | 17 (48.6) | 18 (51.4) |
Current smoker at time of survey | 9 (2.5) | 0 | 4 (44.4) | 5 (55.6) |
Don’t know | 4 (1.1) | 0 | 3 (75.0) | 1 (25.0) |
Solid food pretreatment, No. (%) | ||||
Yes | 356 (99.2) | 6 | 212 (60.6) | 138 (39.4) |
No | 3 (0.8) | 1 | 2 (100.0) | 0 (0.0) |
Treatment group, No. (%) | ||||
Single modality | 118 (32.9) | 5 | 78 (69.0) | 35 (31.0) |
Multimodality | 241 (67.1) | 2 | 136 (56.9) | 103 (43.1) |
Chemotherapy, No. (%) | ||||
No | 118 (32.9) | 5 | 78 (69.0) | 35 (31.0) |
Yes | 241 (67.1) | 2 | 136 (56.9) | 103 (43.1) |
Surgery, No. (%) | ||||
No | 357 (99.4) | 7 | 213 (60.9) | 137 (39.1) |
Yes—robotic | 1 (0.3) | 0 | 1 (100.0) | 0 (0.00) |
Yes—open | 1 (0.3) | 0 | 0 (0.00) | 1 (100.0) |
Neck dissection, No. (%) | ||||
No | 281 (78.3) | 7 | 166 (60.6) | 108 (39.4) |
Yes | 78 (21.7) | 0 | 48 (61.5) | 30 (38.5) |
RT schedule, No. (%) | ||||
Standard fractionation | 302 (84.1) | 6 | 183 (61.8) | 113 (38.2) |
Accelerated | 57 (15.9) | 1 | 31 (55.4) | 25 (44.6) |
Missing/no RT | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
RT type, No. (%) | ||||
3D-CRT | 28 (7.8) | 1 | 10 (37.0) | 17 (63.0) |
IMRT Bilateral (SF + IMRT + WF + VMAT) + Proton | 299 (83.3) | 4 | 183 (62.0) | 112 (38.0) |
IMRT ipsilateral | 32 (8.9) | 2 | 21 (70.0) | 9 (30.0) |
Missing/no | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Parotid gland dose, No. (%) | ||||
Mean parotid gland dose ≤ 26 Gy | 147 (41.0) | 3 | 93 (64.6) | 51 (35.4) |
Mean parotid gland dose > 26 Gy | 96 (26.7) | 0 | 54 (56.2) | 42 (43.8) |
Missing/Don't Know | 116 (32.3) | 4 | 67 (59.8) | 45 (40.2) |
Cluster for population stratification, No. (%) | ||||
Cluster 1 | 69 (19.2) | 2 | 39 (18.2) | 28 (20.3) |
Cluster 2 | 45 (12.5) | 0 | 26 (12.1) | 19 (13.8) |
Cluster 3 | 34 (9.5) | 0 | 24 (11.2) | 10 (7.2) |
Cluster 4 | 33 (9.2) | 1 | 20 (9.3) | 12 (8.7) |
Cluster 5 | 37 (10.3) | 0 | 24 (11.2) | 13 (9.4) |
Cluster 6 | 29 (8.1) | 0 | 16 (7.5) | 13 (9.4) |
Cluster 7 | 8 (2.2) | 0 | 4 (1.9) | 4 (2.9) |
Cluster 8 | 28 (7.8) | 1 | 15 (7.0) | 12 (8.7) |
Cluster 9 | 50 (13.9) | 2 | 33 (15.4) | 15 (10.9) |
Cluster 10 | 16 (4.5) | 0 | 10 (4.7) | 6 (4.3) |
Cluster 11 | 8 (2.2) | 1 | 3 (1.4) | 4 (2.9) |
Cluster 12 | 1 (0.3) | 0 | 0 (0.0) | 1 (0.7) |
Cluster 13 | 1 (0.3) | 0 | 0 (0.0) | 1 (0.7) |
