Figure 4

The effect of cecum content transfer after BMT on cytokine secretion of stimulated peritoneal macrophages. Spiderplots show IL-6 and TNF-α release in response to various pathogenic stimuli from peritoneal macrophages derived from (a) germfree mice inoculated with cecum content samples of BMT-treated mice co-housed with BMT-mice (outer light blue lines), (b) germfree mice inoculated with cecum content samples of BMT-treated mice co-housed with control mice (outer dark blue lines), and (c) germfree mice inoculated with cecum content samples of control mice co-housed with BMT mice (outer red lines). Cytokine concentrations in response to stimuli are normalized to the cytokine concentrations of peritoneal macrophages from germfree mice inoculated with cecum content samples of control mice co-housed with control mice (inner grey lines). See legend to Fig. 1 for more information. Groups were compared using Mann–Whitney U test; n = 4–5.