Table 2 The edgecounts of the targets in the PPI network.

1

AKT1

Protein kinase

67

48

HDAC4

Histone deacetylase 4

15

2

TNF

Tumor necrosis factor

59

49

BCL2A1

Bcl-2-related protein A1

15

3

VEGFA

Vascular endothelial growth factor A

58

50

TLR9

Toll-like receptor 9

15

4

IL6

Interleukin-6

56

51

TOP1

DNA topoisomerase 1

14

5

MAPK3

Mitogen-activated protein kinase 3

54

52

AKR1B1

Aldo–keto reductase family 1 member B1

14

6

CASP3

Caspase-3

54

53

MIF

Macrophage migration inhibitory factor

13

7

IL1B

Interleukin-1 beta

53

54

BCL2

Apoptosis regulator Bcl-2

13

8

TP53

Cellular tumor antigen p53

53

55

MMP8

Neutrophil collagenase

12

9

JUN

Transcription factor AP-1

50

56

ADORA2A

Adenosine receptor A2a

11

10

EGFR

Epidermal growth factor receptor

49

57

RPS6KA3

Ribosomal protein S6 kinase alpha-3

11

11

PTGS2

Prostaglandin G/H synthase 2

45

58

LGALS4

Galectin-4

10

12

HSP90AA1

Heat shock protein HSP 90-alpha

45

59

MGAM

Maltase-glucoamylase, intestinal

10

13

ESR1

Estrogen receptor

45

60

PTGS1

Prostaglandin G/H synthase 1

10

14

MMP9

Matrix metalloproteinase-9

44

61

ADA

Adenosine deaminase

8

15

HRAS

GTPase HRas

40

62

ADORA3

Adenosine receptor A3

8

16

NOS3

Nitric oxide synthase, endothelial

39

63

SELL

L-selectin

8

17

SIRT1

NAD-dependent protein deacetylase sirtuin-1

37

64

MMP12

Macrophage metalloelastase

8

18

BCL2L1

Bcl-2-like protein 1

35

65

EDNRA

Endothelin-1 receptor

7

19

RELA

Transcription factor p65

34

66

MGEA5

Protein O-GlcNAcase

7

20

MAPK1

Mitogen-activated protein kinase 1

33

67

P2RY2

P2Y purinoceptor 2

6

21

MAPK14

Mitogen-activated protein kinase 14

33

68

TYR

Tyrosinase

6

22

MMP2

72 kDa type IV collagenase

32

69

GLP1R

Glucagon-like peptide 1 receptor

6

23

GSK3B

Glycogen synthase kinase-3 beta

31

70

NR2F2

COUP transcription factor 2

6

24

CASP9

Caspase-9

31

71

PSEN2

Presenilin-2

6

25

MCL1

Induced myeloid leukemia cell differentiation protein Mcl-1

31

72

GBA

Lysosomal acid glucosylceramidase

6

26

VCAM1

Vascular cell adhesion protein 1

29

73

PNP

Purine nucleoside phosphorylase

5

27

SOD1

Superoxide dismutase

27

74

SLC6A3

Sodium-dependent dopamine transporter

5

28

CDK2

Cyclin-dependent kinase 2

25

75

PYGM

Glycogen phosphorylase, muscle form

5

29

PTPN1

Tyrosine-protein phosphatase non-receptor type 1

24

76

PTPN2

Tyrosine-protein phosphatase non-receptor type 2

5

30

PIK3CA

PI3-kinase subunit alpha

24

77

S1PR2

Sphingosine 1-phosphate receptor 2

5

31

HSPA5

Endoplasmic reticulum chaperone BiP

24

78

DYRK1A

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

4

32

NOS2

Nitric oxide synthase, inducible

23

79

CA2

Carbonic anhydrase 2

3

33

CCNA2

Cyclin-A2

22

80

CYP2D6

Cytochrome P450 2D6

3

34

MMP3

Stromelysin-1

22

81

SLC5A1

Sodium/glucose cotransporter 1

3

35

MMP1

Interstitial collagenase

21

82

NCSTN

Nicastrin

3

36

SELE

E-selectin

21

83

ATIC

Bifunctional purine biosynthesis protein ATIC

2

37

PTPN11

Tyrosine-protein phosphatase non-receptor type 11

21

84

CYP1A2

Cytochrome P450 1A2

2

38

MMP7

Matrilysin

20

85

CA1

Carbonic anhydrase 1

2

39

FYN

Tyrosine-protein kinase Fyn

20

86

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

2

40

LGALS3

Galectin-3

19

87

ICMT

Protein-S-isoprenylcysteine O-methyltransferase

2

41

SIRT2

NAD-dependent protein deacetylase sirtuin-2

17

88

GAA

Lysosomal alpha-glucosidase

2

42

MMP13

Collagenase 3

17

89

PSENEN

Gamma-secretase subunit PEN-2

2

43

DNMT1

DNA (cytosine-5)-methyltransferase 1

17

90

ADH1A

Alcohol dehydrogenase 1A

1

44

IGFBP3

Insulin-like growth factor-binding protein 3

17

91

FUCA1

Tissue alpha-L-fucosidase

1

45

PLAT

Tissue-type plasminogen activator

16

92

MAG

Myelin-associated glycoprotein

1

46

NOS1

Nitric oxide synthase, brain

15

93

GPR35

G-protein coupled receptor 35

1

47

SELP

P-selectin

15