Table 2 Summary of how each of the selected mutations that have been linked to AF are represented in the LA and PV models. Here, GOF refers to gain-of-function mutations, and LOF refers to loss-of-function mutations. Complete mathematical specifications of each of these modified currents are given in the Supplementary Information.

From: Arrhythmogenic influence of mutations in a myocyte-based computational model of the pulmonary vein sleeve

Mutation

Effect

Modeling

Ref.

N588K

\(I_{\mathrm {Kr}}\) GOF

Transition rates between the open

and inactivated states adjusted

39,41

A545P

\(I_{\mathrm {to}}\) GOF

\(g_{\mathrm {to}}\) increased by 75%

\(\tau _{r_{\mathrm {to}}}\) increased by 15%

42

E299V

\(I_{\mathrm {K1}}\) GOF

\(I_{\mathrm {K1}}\) reformulated

43

E375X

\(I_{\mathrm {Kur}}\) LOF

\(g_{\mathrm {Kur}}\) reduced by 90%

44

A130V

\(I_{\mathrm {Na}}\) LOF

\(g_{\mathrm {Na}}\) reduced by 75%

45

c.932delC

\(I_{\mathrm {gap}}\) LOF

\(G_{\mathrm {gap}}\) reduced by 75%

46

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