Figure 2 | Scientific Reports

Figure 2

From: First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Figure 2

Overview of the holo structure of ΔMtDXPS. (a) Overview of the ΔMtDXPS structure with highlighted domains. Domain I (res 1–312) in red, domain II (res 313–483) in green and domain III (484–638) in cyan. (b) Active site with important residues for catalysis shown in stick representation. (c) Structure colored according to Cα-RMSD to the drDXPS structure (PDB ID: 2O1X), insertion regions are colored in yellow. (d) Hydrogen-bonding network that stabilizes the different H426 conformation and key residues in the network. Water molecules are shown as red spheres and hydrogen bonds as black, dashed lines with distances indicated in Ångström.

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