Figure 3
From: Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
Treatment of mice with obesogenic diets supplemented with myriocin containing Cordyceps reduces body weight and increases energy expenditure. C57Bl6/J mice fed high fat diets supplemented with starch (control), Sample 1 and Sample 6 for 12-weeks. (A) Body mass and (B) Percentage weight gain was determined weekly. (C) Fat, lean and fluid mass were quantified by NMR and (D) organ weight was determined following euthanasia (N = 5–7 animals per group). Following 4-weeks (E–G) and 12-weeks (H–J) of dietary intervention supplemented with Cordyceps animals were placed in metabolic cages (CLAMS) from Columbus Instruments. During the subsequent 3-days, (E,H) oxygen consumption (VO2), (F,I) carbon dioxide production (VCO2) and (G,J) energy expenditure was quantified (N = 4–7 animals per group). Values are expressed as mean ± SEM, *p < 0.05, **p < 0.001, ***p < 0.0001 vs control.
