Figure 4
From: Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
Cordyceps enriched in myriocin alters adipose tissue morphology and elevates adipose tissue thermogenic program. C57Bl6/J mice fed high fat diets supplemented with starch (control), Sample 1 and Sample 6 for 12-weeks. (A) Adipose tissue was evaluated histologically (H&E staining; N = 3–4 animals per group) following euthanasia and (B) images were evaluated to quantify adipocyte size. Following euthanasia, (C) sWAT and BAT depots obtained from Control, Sample 1 and Sample 6 treated mice for 12-weeks were evaluated by immunohistochemistry with antibodies recognizing UCP-1 (N = 4 animals per group). Values are expressed as mean ± SEM, *p < 0.05, **p < 0.001, ***p < 0.0001 vs control. sWAT subcutaneous fat pad, BAT Brown adipose tissue.
