Figure 2
From: Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion
Nobiletin improves mGLUTag L cell metabolic processes following palmitate-induced disruption. (a) Volcano plot of the transcriptome at the peak (8 h) time point of GLP-1 secretion in synchronized palmitate-treated as compared to vehicle (control) mGLUTag L cells. (b, c) Network analysis comparing pathway enrichment between transcriptomes of (b) vehicle- and palmitate-treated, and (c) palmitate- and palmitate + nobiletin-treated mGLUTag L cells at the peak (8 h) GLP-1 secretory time point. Orange dots indicate pathways enriched to the vehicle (b) or palmitate (c) conditions; blue dots indicate pathways enriched to the palmitate- (b) or palmitate + NOB (c) treatment, with the size of the dot indicating the number of genes contained in the pathway. n = 3–4.
