Figure 5 | Scientific Reports

Figure 5

From: Circulating microRNA sequencing revealed miRNome patterns in hematology and oncology patients aiding the prognosis of invasive aspergillosis

Figure 5

Representation of the fold changes in the qRT-PCR data and sequencing read numbers with their density distributions of validated DEMs measured in the whole blood of IA-infected and noninfected HO patients. (a) The downregulated gene expression of 14 DEMs was confirmed by qRT-PCR. Scatter plots represent the whole blood miRNA levels as relative miRNA concentrations with the formula 2-ΔCt (normalized to hsa-miR-181a-5p). Significant median differences in the miRNA levels between each group were determined by the nonparametric Mann–Whitney test (*P < 0.05, **P < 0.01, ***P < 0.001). (b) Density bars represent the normalized sequencing read numbers in patients relative to healthy controls, where the trend line indicates IA-infected (red) and noninfected (blue) patients.

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