Table 2 List of mutations in the corresponding genes encoding resistance to first- and second-line antituberculosis drugs.
Drug | Gene | Mutation |
|---|---|---|
Rifampicin | rpoB | S450L; H445L; A435V; A435T; L452P; c.1302_1307del GGACCA |
Isoniazid | katG | S315T |
inhA | S94A | |
fabG/fabG1 | 15C>T; 8C>T | |
Ethambutol | embB | M306I; M306L; G497A; A435A; T334H; T319C; G406A; S297A; P404S |
embA | 16C>T; 12C>T | |
Pyrazinamide | pncA | T142A; T160A; G10L; H71A; 405_406insCACC; H51A; C138T; A63A; H57A; L27P; P94L; P69L; P63G; V139A; A12A; I133T; I31S; V128G; T34STOP; T68G; L19P; A49G; G97A; *287_287delA; *524_524delT |
Streptomycin | rpsL | L43A; L88A |
rrs | 514a>c; 513c<t; 906a>g | |
Second-line injectables | rrs | 1401a>g |
eis | 12C>T; 10G>A | |
tlyA | c.733_742del | |
Fluoroquinolones | gyrA | A90V; A94G; A94A; S91P |
Ethionamide | fabG | 15C>T; 8T>C |
ethA | 110_110del; 1054_1054del; T314I; M1A; 4327275_4327547del; 1010_1010del; 341_341del; 32_32del; 1386_1386del | |
inhA | S94A | |
Para-aminosalicylic acid | folC | A49P; G40G |
Linezolid | rplC | C154A |
Delamanid | ddn | T88STOP |
