Table 6 Stratified analyses based on clinical features for the association between TLR7 polymorphism and the risk of Knee OA.

From: Association of X-linked TLR-7 gene polymorphism with the risk of knee osteoarthritis: a case–control study

SNPs

Genotype

Clinical features items

OR (95% CI)

P-value

  

BMI < 24

BMI ≥ 24

  

rs3853839

G/G-C/C

44 (77.2%)

62 (69.7%)

1

0.99

C/G

13 (22.8%)

27 (30.3%)

0.99 (0.34–2.89)

rs179010

C/C-T/T

39 (68.4%)

57 (64%)

1

0.2

C/T

18 (31.6%)

32 (36%)

0.51 (0.18–1.44)

  

Age > 55

Age ≤ 55

  

rs3853839

G/G-C/C

47 (69.1%)

59 (75.6%)

1

0.38

C/G

21 (30.9%)

19 (24.4%)

0.72 (0.34–1.51)

rs179010

G/G-C/C

47 (69.1%)

59 (75.6%)

1

0.38

C/G

21 (30.9%)

19 (24.4%)

0.72 (0.34–1.51)

  

KLG ≤ 3

KLG = 4

  

rs3853839

G/G-C/C

130 (81.2%)

82 (89.1%)

1

0.066

C/G

30 (18.8%)

10 (10.9%)

0.48 (0.21–1.08)

rs179010

C/C-T/T

125 (78.1%)

77 (83.7%)

1

0.2

C/T

35 (21.9%)

15 (16.3%)

0.63 (0.31–1.29)

  

Smoke = No

Smoke = Yes

  

rs3853839

G/G-C/C

135 (79.4%)

77 (93.9%)

1

0.53

C/G

35 (20.6%)

5 (6.1%)

0.71 (0.24–2.08)

rs179010

C/C-T/T

128 (75.3%)

74 (90.2%)

1

0.91

C/T

42 (24.7%)

8 (9.8%)

0.95 (0.37–2.40)

  1. Knee OA osteoarthritis patients group, HC healthy control group, OR Odds ratios, CI confidence intervals, KLG Kellgren-Lawrence grade, BMI Body Mass Index. The data adjusted by moke + drinking + age + BMI.
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