Figure 5 | Scientific Reports

Figure 5

From: Irisin protects cardiomyocytes against hypoxia/reoxygenation injury via attenuating AMPK mediated endoplasmic reticulum stress

Figure 5

Irisin blunted H/R induced apoptosis via an AMPK-mediated manner. To investigate the effect of the AMPK signal pathway in cardioprotection of irisin, the AMPK inhibitor compound C was used to pretreat cardiomyocytes(20 μM, 1 h) before irisin pre-treatment, and the AMPK activator metformin pretreats (2.5 mM, 1 h) group was used to make a comparison of apoptosis (A), caspase-3 activities (B), cell viability (C), and LDH activity (D). *P < 0.05 versus control group, #P < 0.05 versus H/R group, $P < 0.05 versus Irisin + H/R group, n = 6.

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