Table 3 Colocalization of human and viral transducer DBRs and MS-GWAS positions (at ± 50,100,200 kb range of extension) in DNA regions coding for transient transcripts; significant results (p < 0.05, corresponding to a − log (p) > 1.301) in bold.

From: Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome

 

 ± 50 KB ± 50 KB

 ± 100 KB

 ± 200 KB

 

− log (pValue)

Odds ratio

Support

Harmonic Score

− log (pValue)

Odds ratio

Support

Harmonic score

− log (pValue)

Odds ratio

Support

Harmonic score

EBNA2

Long half-life

0.023

0.478

3

0.644

0.062

0.717

8

1.708

1.879

1.531

33

24.679

Short half-life

6.163

1.920

69

43.011

3.241

1.433

95

29.496

8.945

1.610

189

40.642

EBNA3C

Long half-life

0.064

0.572

2

1.669

0.006

0.321

2

0.185

0.182

0.914

11

4.500

Short half-life

0.070

0.794

16

1.923

0.023

0.752

28

0.661

0.066

0.875

58

1.841

AID

Long half-life

0.089

0.682

3

2.303

0.283

1.024

8

6.477

0.051

0.726

11

1.432

Short half-life

1.769

1.465

37

23.531

1.346

1.267

59

19.367

3.954

1.442

119

31.416

VDR

Long half-life

1.737

1.502

32

23.571

0.845

1.187

45

14.646

2.315

1.322

97

25.031

Short half-life

2.221

1.239

152

23.734

2.336

1.181

267

23.460

11.478

1.367

548

36.561

  1. The transcript half-life is considered short if < 60′ and long if ≥ 60′, respectively.
Back to article page