Table 4 Activity-By-Contact (ABC) functional mapping of MS-trRNA hotspots bound by 4/4 MS-relevant transducers or only 3/4 (AID,EBNA2, VDR).
From: Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome
MS SNP-TrRNA hotspot | Transducers | Chr | Position | GWAS catalog reported gene | ABC linked gene |
|---|---|---|---|---|---|
rs11026091 | 4/4 | 11 | 3,238,579 | MRGPRE | MRGPRG-AS1, MRGPRG, MRGPRE |
rs11008218 | 4/4 | 10 | 30,744,074 | SVILP1 | MAP3K8 |
rs12048904 | 4/4 | 1 | 100,865,980 | EXTL2 | GPR88, CDC14A, RTCA-AS1, RTCA-AS1 |
rs11666377 | 3/4 | 19 | 17,007,623 | CPAMD8 | F2RL3, HAUS8, MYO9B, NWD1, SIN3B |
rs11669861 | 3/4 | 19 | 19,166,593 | MEF2B, MEF2BNB-MEF2B | SLC25A42 |
rs12909611 | 3/4 | 15 | 60,865,204 | RORA | ICE2,RORA-AS1,RORA-AS2 |
rs1250551 | 3/4 | 10 | 79,299,578 | ZMIZ1 | KCNMA1 |
rs1152430 | 3/4 | 14 | 90,906,615 | RPS6KA5 | CALM1, LINC00642, LOC105370619, LOC105370622 |
rs11762408 | 3/4 | 7 | 150,676,640 | GIMAP6 | ABCB8, AOC1, GIMAP8, KCNH2, TMEM176A, TMEM176B |
rs10931933 | 3/4 | 2 | 201,247,748 | CASP8 | SPATS2L, KCTD18 |
