Figure 3
pEVs release over time. (a) Percentage of released EVs after 14 days for Ti-EVs, NN-EVs and D-EVs. (b) Accumulative pEVs release for each functionalized implant measured after 2, 6, 10 and 14 days. (c) Released pEVs according to size at 2, 6, 10 and 14 days. Small EVs (pale gray) correspond to sizes smaller than 100 nm, medium EVs (gray) are between 100 and 150 nm and large EVs (dark gray) are larger than 150 nm. Values represent the mean ± SEM and they were compared by ANOVA, using DMS as post hoc for data of 2 days and 10 days, and Games-Howell as post hoc for data of 6 days and 14 days. Three different samples were evaluated per group and statistically significant differences were considered for p < 0.05 and represented with acompared to Ti-EVs and bcompared to NN-EVs.
