Figure 5 | Scientific Reports

Figure 5

From: Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer’s disease

Figure 5

A comparison of power values immediately after and before AD-tau injection as well as power values at 1 m.p.i. (a) Log power bar plots from 3-and 6-month-old animals showing immediate changes in Theta 2, Low and High Gamma power at Pre-injection (Pre) and Post-injection (Post). (b) Bar plot comparisons of 3-month-old animals for each of the bands investigated for pre- and post-injection changes in power spectra at 1 m.p.i. (c) Bar plot comparisons of 6-month-old animals for each of the bands investigated for pre- and post-injection changes in power spectra at 1 m.p.i. (Due to the impact of Covid-19 lockdowns, several datapoints from the 6-month-old 1 m.p.i. timepoint for WT- Buffer group could not be obtained, thus resulting in n = 3). Log Power spectra from 1 to 100 Hz of the retrosplenial cortex of (d) 3-month-old animals and (e) 6-month-old animals at 5 months post injection. (m.p.i. refers to months post injection). All bar plots are Mean + SEM. Asterisks indicate significant comparisons (p < 0.05).

Back to article page