Table 4 Multivariable Cox Proportional Hazard Models considering as dependent variable the occurrence of the first CV event during follow-up.

From: Persistence of C-reactive protein increased levels and high disease activity are predictors of cardiovascular disease in patients with axial spondyloarthritis

 

Model 1 (corrected for age and gender)

Model 2 (corrected for age, gender, and diabetes)

Model 3 (corrected for age, gender, acetyl-salicylic acid and statin treatments)

Model 4 (corrected for age, gender, and anti-hypertensive treatment)

HR (95%CI)

p

HR (95%CI)

p

HR (95%CI)

p

HR (95%CI)

p

Time percentage of elevated CRP during follow-up

1.028 (1.013–1.042)

 < 0.001

1.030 (1.015–1.045)

 < 0.001

1.027 (1.012–1.042)

 < 0.001

1.027 (1.12–1.042)

 < 0.001

Time percentage of ASDAS-CRP > 2.1 during follow-up

1.014 (1.001–1.027)

0.03

1.014 (1.000- 1.028)

0.047

1.013 (1.000–1.027)

0.05

1.013 (1.001–1.026)

0.037

Time percentage of BASDAI > 4 during follow-up

1.019 (1.006–1.033)

0.004

1.019 (1.006–1.033)

0.006

1.021 (1.006–1.035)

0.005

1.018 (1.004–1.031)

0.01

  1. Each independent variable (time percentage of elevated CRP during follow-up; time percentage of ASDAS-CRP > 2.1 during follow-up; or time percentage of BASDAI > 4 during follow-up) was tested in four models: model 1, corrected for age and gender; model 2, corrected for age, gender, and diabetes; model 3, corrected for age, gender, acetyl-salicylic acid and statin treatments; model 4, corrected for age, gender, and anti-hypertensive treatment. HR hazard ratio; CI confidence interval; CRP C-reactive protein; ESR erythrocyte sedimentation rate; BASDAI Bath Ankylosing Spondylitis Disease Activity Index; ASDAS Ankylosing Spondylitis Disease Activity Score.
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