Table 5 Active PPI use: outcomes based on PPI dosage (n = 286)*.

From: Proton pump inhibitor therapy usage and associated hospitalization rates and critical care outcomes of COVID-19 patients

 

Low

(n = 70)

Standard

(n = 190)

High

(n = 26)

p-value**

Hospital admission within two weeks of COVID testing

(n,%)

68 (97.1%)

182 (95.8%)

25 (96.2%)

.88

ICU admission

(n,%)

16 (22.9%)

52 (27.4%)

9 (34.6%)

.50

Hospital length of stay, days

(median, range)

1 (1–33)

3 (1–32)

3.5 (1–45)

.07

Oxygen use

(n,%)

Mechanical ventilation: 7 (10%)

BPAP: 1 (1.4%)

Supplemental: 47 (67.1%)

None: 15 (21.4%)

Mechanical ventilation: 28 (14.7%)

BPAP: 1 (0.5%)

Supplemental: 106 (55.8%)

None: 55 (28.9%)

Mechanical ventilation: 6 (23.1%)

BPAP: 0

Supplemental: 14 (53.8%)

None: 6 (23.1%)

.47

30-day mortality

(n,%)

10 (14.3%)

37 (19.5%)

7 (26.9%)

.35

  1. *PPI Proton pump inhibitor.
  2. **Based on separate chi square or Kruskal Wallis tests, as appropriate.