Table 2 Top 5 significant transcripts from M1, top 2 significant genes from M2, significant Gene Ontology terms from M3, and significant Reactome pathways from M4.

From: Identification of functional features underlying heat stress response in Sprague–Dawley rats using mixed linear models

Tissue

Model

ID name

Effect

P

Liver

Transcript (M1)

ENSRNOT00000074131

PNKD

2.76

4.7 × 10–10

Transcript (M1)

ENSRNOT00000093245

TRIP12

2.15

1.2 × 10–6

Transcript (M1)

ENSRNOT00000093735

TRIP12

1.67

0.00016

Transcript (M1)

ENSRNOT00000022822

TRIP12

1.65

0.00021

Transcript (M1)

ENSRNOT00000079452

TRIP12

1.63

0.00023

Gene (M2)

ENSRNOG00000016963

TRIP12

1.66

3.5 × 10–5

Gene (M2)

ENSRNOG00000014806

PNKD

1.12

0.00520

Gene ontology (M3)

GO:1901315

Negative regulation of histone H2A K63-linked ubiquitination

0.52

0.00055

Gene ontology (M3)

GO:2000780

Negative regulation of double-strand break repair

0.48

0.00130

Gene ontology (M3)

GO:2000779

Regulation of double-strand break repair

0.37

0.01300

Gene ontology (M3)

GO:0045995

Regulation of embryonic development

0.30

0.04200

Gene ontology (M3)

GO:0002181

Cytoplasmic translation

0.29

0.05200

Reactome pathway (M4)

R-RNO-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

0.29

0.05500

Adrenal

Transcript (M1)

ENSRNOT00000075998

SUCO

3.48

9.2 × 10–11

Transcript (M1)

ENSRNOT00000084058

SUCO

2.18

4.9 × 10–5

Transcript (M1)

ENSRNOT00000082271

PLEC

2.10

8.9 × 10–10

Transcript (M1)

ENSRNOT00000075936

SUCO

1.95

0.00029

Transcript (M1)

ENSRNOT00000088945

PLEC

1.70

0.00160

Gene (M2)

ENSRNOG00000026542

SUCO

2.26

8.4 × 10–6

Gene (M2)

ENSRNOG00000018413

PER3

1.63

0.00130

Reactome pathway (M4)

R-RNO-212436

Generic Transcription Pathway

0.49

0.00500

  1. ID the Ensembl transcript ID, Ensembl gene ID Gene Ontology database ID, or Reactome ID, depending on the effect considered, Effect represents the estimate from the corresponding mixed model M1–M4, P P value corresponding to the normal probability density function with mean zero and the variance estimated by the corresponding model.