Figure 9 | Scientific Reports

Figure 9

From: Characterization of NRPS and PKS genes involved in the biosynthesis of SMs in Alternaria dauci including the phytotoxic polyketide aldaulactone

Figure 9

Proposed biosynthetic pathway of aldaulactone in A. dauci. The HR-PKS (AdPKS7) produces a reduced triketide. This triketide becomes the starter unit of the NR-PKS (AdPKS8). AdPKS8 catalyzes the addition of four more malonyle-CoA units. The AdPKS8 PT domain catalyzes a C3–C8 aldol condensation. AdPKS8 TE domain then catalyzes the macrolactone cyclisation. Afterward, the cluster 8 oxidase catalyzes the addition of an alcohol function on C6 of the benzene diol. Finally, the methylation of the C6 alcohol function is catalyzed by the cluster 8 methyl transferase.

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