Table 2 The correlation of C17 CNVs with clinicopathological features of CCA patients.
Variables | No | CNV of C17, n (%) | P-value | ||
|---|---|---|---|---|---|
Disomy | Trisomy | > Trisomy | |||
Age (year) | |||||
< 60 | 87 | 33 (62.3%) | 9 (45.0%) | 45 (53.6%) | 0.341 |
≥ 60 | 70 | 20 (37.7%) | 11 (55.0%) | 39 (46.4%) | |
Gender | |||||
Male | 80 | 26 (49.1%) | 15 (75.0%) | 39 (46.4%) | 0.063 |
Female | 77 | 27 (50.9%) | 5 (25.0%) | 45 (53.6%) | |
ASTa | |||||
< 40 | 50 | 18 (36.0%) | 13 (68.4%) | 19 (38%) | 0.032*† |
≥ 40 | 69 | 32 (64.0%) | 6 (31.6%) | 31 (62%) | |
ALT | |||||
< 40 | 54 | 19 (38.0%) | 12 (63.2%) | 23 (46.9%) | 0.191 |
≥ 40 | 64 | 31 (62.0%) | 7 (36.8%) | 26 (53.1%) | |
ALP | |||||
< 130 | 42 | 20 (40.0%) | 4 (22.2%) | 18 (36%) | 0.547 |
≥ 130 | 76 | 30 (60.0%) | 14 (77.8%) | 32 (64% | |
Tumor size (cm) | |||||
Small (≤ 5 cm) | 96 | 37 (69.8%) | 12 (60.0%) | 47 (56%) | 0.210 |
Large (> 5 cm) | 61 | 16 (30.2%) | 8 (40.0%) | 37 (44%) | |
Anatomical position | |||||
Intrahepatic | 63 | 24 (45.3%) | 7 (35.0%) | 32 (38.1%) | 0.844 |
Extrahepatic | 94 | 29 (54.7%) | 13 (65.0%) | 52 (61.9%) | |
Gross pathologyb | |||||
ID | 31 | 17 (32.1%) | 4 (21.1%) | 10 (12%) | 0.023# |
PI | 45 | 17 (32.1%) | 6 (31.6%) | 22 (26.5%) | |
MF | 34 | 6 (11.3%) | 2 (10.5%) | 26 (31.3%) | |
Mixed types | 45 | 13 (24.5%) | 7 (36.8%) | 25 (30.2%) | |
Histologic type | |||||
Non-Papillary | 75 | 24 (45.3%) | 9 (47.4%) | 42 (49.4%) | 0.885 |
Papillary | 82 | 29 (54.7%) | 10 (52.6%) | 43 (50.6%) | |
Lymph node metastasisc | |||||
No | 78 | 40 (74.1%) | 9 (45.0%) | 29 (34.9%) | < 0.001*# |
Yes | 79 | 14 (25.9%) | 11 (55.0%) | 54 (65.1%) | |
Gall bladder metastasis d | |||||
No | 130 | 50 (94.3%) | 19 (95.0%) | 61 (72.6%) | < 0.001#† |
Yes | 27 | 3 (5.7%) | 1 (5.0%) | 23 (27.4%) | |
Distant metastasise | |||||
No | 117 | 51 (96.2%) | 16 (80.0%) | 50 (59.5%) | < 0.001*# |
Yes | 40 | 2 (3.8%) | 4 (20.0%) | 34 (40.5%) | |
