Table 3 Univariate analysis of the clinicopathological factors and metastasis.

From: Fluorescence in situ hybridization detection of chromosome 7 and/or 17 polysomy as a prognostic marker for cholangiocarcinoma

Variables

No

Lymph node metastasis

GB metastasis

Distant metastasis

OR (95%CI)

P-value

OR (95%CI)

P-value

OR (95%CI)

P-value

Age (year)

 < 60

87

1

 

1

 

1

 

 ≥ 60

70

0.646 (0.343–1.217)

0.176

0.566 (0.237–1.352)

0.200

1.534 (0.746–3.155)

0.245

Gender

Male

81

1

 

1

 

1

 

Female

77

0.951 (0.509–1.774)

0.874

0.972 (0.424–2.227)

0.947

1.224 (0.597–2.509)

0.582

AST

 < 40

50

1

 

1

 

1

 

 ≥ 40

69

0.971 (0.469–2.012)

0.938

1.702 (0.599–4.840)

0.318

0.956 (0.406–2.251)

0.918

ALT

 < 40

54

1

 

1

 

1

 

 ≥ 40

64

0.714 (0.345–1.478)

0.364

1.193 (0.442–3.220)

0.727

0.548 (0.233–1.292)

0.169

ALP

 < 130

42

1

 

1

 

1

 

 ≥ 130

76

1.562 (0.731–3.338)

0.250

3.467 (0.947–12.686)

0.060

01.417 (0.560–3.586)

0.462

Tumor size (cm)

Small (≤ 5 cm)

97

1

 

1

 

1

 

Large (> 5 cm)

61

1.307 (0.687–2.484)

0.414

0.923 (0.392–2.173)

0.854

2.155 (1.040–4.465)

0.039

Anatomical position

Intrahepatic

63

1

 

1

 

1

 

Extrahepatic

95

3.524 (1.797–6.908)

 < 0.001

4.712 (1.543–14.386)

0.006

0.864 (0.417–1.790)

0.695

Gross pathology

ID

31

1

 

1

 

1

 

PI

45

5.702 (1.957–16.614)

0.001

7.778 (0.898–67.364)

0.063

1.038 (0.267–4.034)

0.957

MF

34

4.687 (1.534–14.322)

0.007

9.706 (1.182–79.670)

0.034

7.594 (2.181–26.437)

0.001

Mixed types

45

5.702 (1.957–16.614)

0.001

5.526 (0.644–47.408)

0.119

2.455 (0.710–8.487)

0.156

Histology type

Non-papillary

75

1

 

1

 

1

 

Papillary

82

1.082 (0.576–2.032)

0.807

0.745 (0.320–1.735)

0.495

0.473 (0.225–0.995)

0.048

C7

Disomy

49

1

 

1

 

1

 

Trisomy

43

3.546 (1.464–8.591)

0.005

1.573 (0.332–7.458)

0.569

11.345 (2.403–53.568)

0.002

 > Trisomy

66

6.027 (2.629–13.812)

 < 0.001

6.815 (1.893–24.539)

0.003

13.756 (3.063–61.778)

0.001

C17

Disomy

54

1

 

1

 

1

 

Trisomy

20

3.492 (1.197–10.188)

0.022

0.895 (0.088–9.138)

0.925

6.500 (1.088–38.833)

0.040

 > Trisomy

84

5.048 (2.371–10.746)

 < 0.001

6.131 (1.735–21.665)

0.005

17.160 (3.910–75.318)

 < 0.001

C7/17

Disomy

47

1

 

1

 

1

 

Trisomy

18

4.583 (1.448–14.509)

0.010

0.863 (0.084–8.879)

0.901

9.200 (0.889–95.221)

0.063

 > Trisomy

60

5.417 (2.331–12.590)

 < 0.001

5.333 (1.451–19.609)

0.012

24.769 (3.186–192.588)

0.002

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