Table 5 Univariate of clinicopathological parameters, chromosomal aberrations and overall survival time.
Variables | Number | Median OS (months) | Univariate | |
|---|---|---|---|---|
HR (95%CI) | P-value | |||
Age (year) | ||||
< 60 | 84 | 12.75 | 1 | |
≥ 60 | 69 | 9.97 | 1.157 (0.839–1.596) | 0.374 |
Gender | ||||
Male | 80 | 12.94 | 1 | |
Female | 74 | 8.99 | 0.852 (0.613–1.183) | 0.338 |
AST | ||||
< 40 | 49 | 15.97 | 1 | |
≥ 40 | 67 | 16.13 | 0.664 (0.447–0.987) | 0.043 |
ALT | ||||
< 40 | 52 | 14.48 | 1 | |
≥ 40 | 63 | 17.43 | 0.763 (0.525–1.111) | 0.158 |
ALP | ||||
< 130 | 42 | 16.92 | 1 | |
≥ 130 | 73 | 15.53 | 1.161 (0.791–1.705) | 0.445 |
Tumor size (cm) | ||||
Small (≤ 5 cm) | 95 | 13.73 | 1 | |
Large (> 5 cm) | 59 | 9.17 | 1.385 (0.996–1.926) | 0.053 |
Lymph node metastasis | ||||
No | 78 | 19.72 | 1 | |
Yes | 76 | 7.20 | 2.498 (1.772–3.520) | < 0.001 |
Gall bladder metastasis | ||||
No | 130 | 13.22 | 1 | |
Yes | 24 | 2.73 | 1.809 (1.159–2.823) | 0.009 |
Distant metastasis | ||||
No | 116 | 16.18 | 1 | |
Yes | 38 | 7.00 | 2.104 (1.427–3.102) | < 0.001 |
Anatomical position | ||||
Intrahepatic | 63 | 12.70 | 1 | |
Perihilar Extrahepatic | 83 | 11.53 | 1.100 (0.789–1.532) | 0.574 |
Distal Extrahepatic | 8 | 16.25 | 1.098 (0.525–2.296) | 0.804 |
Anatomical position | ||||
Intrahepatic | 63 | 12.70 | 1 | |
Extrahepatic | 91 | 11.53 | 1.100 (0.795–1.521) | 0.567 |
Gross pathology | ||||
ID | 30 | 24.54 | 1 | |
PI | 43 | 15.33 | 1.367 (0.852–2.194) | 0.195 |
MF | 34 | 5.67 | 2.473 (1.492–4.099) | < 0.001 |
Mixed types | 44 | 11.03 | 1.572 (0.983–2.513) | 0.059 |
Histology type | ||||
Non-papillary | 75 | 10.32 | 1 | |
Papillary | 82 | 12.70 | 0.763 (0.548–1.062) | 0.109 |
C7 | ||||
Disomy | 49 | 49.77 | 1 | |
Trisomy | 43 | 13.07 | 4.723 (2.405–9.275) | < 0.001 |
> Trisomy | 62 | 2.23 | 112.113 (48.080–261.425) | < 0.001 |
C17 | ||||
Disomy | 54 | 45.83 | 1 | |
Trisomy | 20 | 15.53 | 29.862 (11.247–79.291) | < 0.001 |
> Trisomy | 80 | 3.03 | 495.067 (134.308–1824.839) | < 0.001 |
C7/17 | ||||
Disomy | 47 | 50.23 | 1 | |
Trisomy | 18 | 15.33 | 31.864 (12.257–89.391) | < 0.001 |
> Trisomy | 60 | 2.23 | 253.020 (27.124–2360.244) | < 0.001 |
