Figure 1
From: Doxorubicin impacts chromatin binding of HMGB1, Histone H1 and retinoic acid receptor
Doxorubicin affects HMGB1 dynamics in a concentration dependent manner. (a) Representative nuclei of U2OS2FP cells treated with the indicated concentrations of Dox for 2 h. (b) GFP-HMGB1 recovery times of Dox-treated cells as measured by point FRAP. The graph shows one representative experiment of three repeats. In this as well as in the other figures, box-and-whiskers plots represent 10th, 25th, 50th, 75th, and 90th percentiles; + , mean value. One-way ANOVA with post hoc Dunnett’s test was used to calculate significance compared to 0 Dox (**p < 0.01, ****p < 0.0001). Data were analyzed using GraphPad Prism 8.01.
