Figure 4
From: Doxorubicin impacts chromatin binding of HMGB1, Histone H1 and retinoic acid receptor
Doxorubicin affects histone H1c binding to genomic DNA in a dose- and time-dependent manner. (a) Representative images of H1c-GFP expressor HeLa cells treated with Dox for 30 (top row) or 120 min (bottom row). (b) FRAP analysis of H1c-GFP intranuclear mobility without Dox treatment and after 30 min treatment with different concentrations of the drug. One-way ANOVA with post hoc Dunnett’s test was used to calculate significance (****p < 0.0001).
