Figure 5
From: A new non-human primate model of desiccating stress-induced dry eye disease
TFBUT and cytokine levels in tears following topical corticosteroid treatment. Rhesus monkeys were housed in a controlled environment room for 21 days to induce evaporative dry eye. From day 21 post-dry eye induction (Day 0 of treatment), both corneas were topically treated with two drops of Pred Forte 1% or normal saline (placebo) thrice daily for 14 days. (A) Bar chart showing TFBUT in Pred Forte 1% or placebo-treated corneas on days 0, 7 and 14 post-treatment initiation. (B) Tear wash (25 µL/wash) was collected on day 0 and 14 post-treatment initiation to measure the levels of proinflammatory cytokines, IL-17, TNF-α, IFN-γ and IL-2. Bar chart showing fold change in proinflammatory cytokines in tears of Pred Forte 1% or placebo-treated corneas on day 14 post-treatment. (Fold change from treatment day 0; 1 representing no change in cytokine levels). Representative data from two independent experiments are shown, each treatment group consisted of n = 6 eyes/group. Data are represented as mean ± SEM (error bar). t-test; *p < 0.05, **p < 0.01.
