Figure 5 | Scientific Reports

Figure 5

From: Formaldehyde exposure induces differentiation of regulatory T cells via the NFAT-mediated T cell receptor signalling pathway in Yucatan minipigs

Figure 5

Schematic of the minipig mask-type inhalation system for FA exposure, experimental design, and FA concentrations for assessing the effect of FA exposure on minipigs. (a) FA was generated using a gas bubbler and diluted with clean air using a multi-neck flask. (b) All minipigs received mask training for 2 h per day before FA exposure. Minipigs in the treatment groups were exposed to FA for a period of 2 weeks at 2 h/day, 5 days a week using the minipig mask-type inhalation system. The (c) mean and (d) daily concentrations of FA exposure were monitored using a Top Solid DNPH cartridge and HPLC system. The groups of Yucatan minipigs were exposed to 0 mg/m3 (control), 2.16 ± 0.16 mg/m3, 4.62 ± 0.36 mg/m3, or 10.48 ± 0.64 mg/m3 FA for 2 weeks (5 days/week) at 2 h/day. Data are presented as the mean ± SD. FA formaldehyde.

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