Table 2 Hazard ratios derived from the four predictive models fitted: model C.1 considers age as categorical variable; model C.2 considers age as linear continuous variable; model C.3 considers restricted cubic splines on age; model C.4 considers restricted cubic splines on age and adherence as time varying.
C.1 (age: categorical) | C.2 (age: linear) | C.3 (age: splines) | C.4 (age: splines/adherence: time-varying) | |||||
|---|---|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | Hazard ratio | 95% CI | Hazard ratio | 95% CI | Hazard ratio | 95% CI | |
Age | ||||||||
≤ 49 years | Ref | – | – | – | ||||
50–59 years | 1.44 | 0.91–2.88 | – | – | – | |||
60–74 years | 2.08 | 1.37–3.18 | – | – | – | |||
75–84 years | 6.14 | 4.08–9.25 | – | – | – | |||
HER2 status | ||||||||
Negative | Ref | Ref | Ref | Ref | ||||
Positive | 0.95 | 0.69–1.30 | 0.97 | 0.71–1.34 | 0.97 | 0.71–1.33 | 0.98 | 0.71–1.34 |
Stage | ||||||||
I | Ref | Ref | Ref | Ref | ||||
II | 2.25 | 1.54–3.28 | 2.43 | 1.67–3.52 | 2.24 | 1.51–3.30 | 2.22 | 1.53–3.21 |
III | 5.41 | 3.67–7.92 | 5.71 | 3.91–8.34 | 5.11 | 3.46–7.51 | 4.98 | 3.38–7.32 |
Adherence rate | ||||||||
≤ 80% | Ref | Ref | Ref | – | ||||
> 80% | 0.58 | 0.42–0.82 | 0.54 | 0.39–0.76 | 0.57 | 0.41–0.79 | – | |
Adherence (time varying) | ||||||||
Yes, follow-up ≥ 5 years | – | – | – | 0.57 | 0.38–0.84 | |||
Yes, follow-up < 5 years | – | – | – | 0.58 | 0.33–0.87 | |||
Ratio follow-up ≤ 5/ follow-up > 5*** | – | – | – | 1.02 | 0.51–2.02 | |||
AIC | 2759.12 | 2753.25 | 2747.59 | 2759.54 | ||||
