Table 3 The association between the changes of serum adiponectin levels and changes of lumbar spine/total proximal femur BMD and t-score using generalized estimating equation (GEE) models.

Serum adiponectin level (mg/dL)	Lumbar spine				Total proximal femur
	BMD(g/cm²)		T-score		BMD(g/cm²)		T-score
	β (SE)	P	β (SE)	P	β (SE)	P	β (SE)	P
Model I	− 0.0004(0.0004)	0.264	− 0.007(0.003)	0.031	− 0.001 (0.0004)	0.013	− 0.011(0.003)	0.001
Model II	− 0.0004(0.0004)	0.243	− 0.007(0.003)	0.027	− 0.001 (0.0004)	0.011	− 0.001(0.003)	0.001
Model III	− 0.0006(0.0004)	0.121	− 0.005(0.003)	0.143	− 0.001 (0.0004)	0.008	− 0.009(0.003)	0.008
Model IV	− 0.0005(0.0004)	0.206	− 0.004(0.003)	0.239	− 0.0008(0.0004)	0.026	− 0.007(0.003)	0.025
Model V	− 0.0005(0.0004)	0.167	− 0.004(0.003)	0.195	− 0.0008(0.0004)	0.029	− 0.007(0.003)	0.028
Model VI	− 0.0003(0.0004)	0.373	− 0.003(0.003)	0.390	− 0.0007(0.0004)	0.050	− 0.006(0.003)	0.050

Model I: adjusted for time and time².
Model II: adjusted for age, time and time².
Model III: adjusted for age, time, time², isoflavone treatment, hospital sites, history of diabetes, hypertension and hyperlipidemia as well as average total METs spent and total calories consumed.
Model IV: Model III plus body mass index.
Model V: Model IV plus bone alkaline phosphatase.
Model VI: Model IV plus urinary N-telopeptide of type 1 collagen/creatinitine.

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