Table 1 Patient characteristics according to MI/stroke, SCD, HF rehospitalization overall in the sex and age-matched COMMANDER HF population.
Characteristic | All events | |||
|---|---|---|---|---|
Controls | Cases | SMD (%) | p | |
(n = 455) | (n = 485) | |||
Age (yrs) | 67.4 ± 10.0 | 67.3 ± 10.3 | 1.40 | 0.83 |
Study drug | 210 (46.2%) | 230 (47.3%) | 2.30 | 0.74 |
Female sex | 110 (24.2%) | 120 (24.7%) | 1.20 | 0.88 |
Race | 14.60 | 0.75 | ||
White | 405 (89.0%) | 433 (89.1%) | ||
Black | 2 (0.4%) | 5 (1.0%) | ||
Asian | 42 (9.2%) | 41 (8.4%) | ||
Other | 6 (1.3%) | 7 (1.4%) | ||
Region | 21.50 | 0.13 | ||
Eastern Europe | 315 (69.2%) | 332 (68.3%) | ||
North America | 5 (1.1%) | 9 (1.9%) | ||
Asia Pacific | 42 (9.2%) | 41 (8.4%) | ||
Latin America | 50 (11.0%) | 38 (7.8%) | ||
Western Europe | 43 (9.5%) | 66 (13.6%) | ||
BMI (kg/m2) | 27.6 ± 5.0 | 27.9 ± 5.1 | 6.30 | 0.33 |
eGFR (ml/min/1.73 m2) | 70.1 ± 22.9 | 64.7 ± 23.0 | 23.80 | 0.0003 |
eGFR (ml/min/1.73 m2) | 23.60 | 0.0051 | ||
< 30 ml/min/1.73 m2 | 11 (2.4%) | 25 (5.1%) | ||
30 to < 60 ml/min/1.73 m2 | 157 (34.5%) | 199 (40.9%) | ||
60 to < 90 ml/min/1.73 m2 | 204 (44.8%) | 201 (41.4%) | ||
≥ 90 ml/min/1.73 m2 | 83 (18.2%) | 61 (12.6%) | ||
BNP level (pg/ml) | 875.2 ± 787.4 | 950.3 ± 727.8 | 9.90 | 0.53 |
Log2 BNP (pg/ml) | 6.4 ± 0.8 | 6.6 ± 0.7 | 21.70 | 0.17 |
BNP rank (pg/ml) | ||||
NT-proBNP (pg/ml) | 5869 ± 8707 | 5568 ± 7310 | 3.70 | 0.66 |
Log2 NT-proBNP (pg/ml) | ||||
NT-proBNP rank | 265.8 ± 160.5 | 281.2 ± 154.9 | 9.80 | 0.26 |
d-dimer level (mg/l) | 637.2 ± 1012.5 | 732.3 ± 1027.4 | 9.30 | 0.16 |
Log2 d-dimer | 6.0 ± 0.9 | 6.2 ± 0.8 | 24.40 | 0.0002 |
d-dimer rank | ||||
Ejection fraction (%) | 33.1 ± 6.7 | 31.1 ± 7.3 | 28.40 | < 0.0001 |
Ejection fraction rank | 511.5 ± 267.6 | 433.0 ± 269.1 | 29.30 | < 0.0001 |
NYHA | 12.40 | 0.031 | ||
I/II | 238 (52.4%) | 226 (46.5%) | ||
III | 214 (47.0%) | 246 (50.6%) | ||
IV | 3 (0.7%) | 14 (2.9%) | ||
Myocardial infarction | 331 (72.7%) | 385 (79.2%) | 15.20 | 0.022 |
Stroke | 44 (9.7%) | 58 (11.9%) | 7.30 | 0.29 |
Diabetes | 163 (35.8%) | 223 (45.9%) | 20.60 | 0.002 |
Hypertension | 339 (74.5%) | 375 (77.2%) | 6.20 | 0.36 |
ACEI or ARB | 431 (94.7%) | 452 (93.0%) | 7.20 | 0.28 |
Beta blockers | 424 (93.2%) | 445 (91.6%) | 6.10 | 0.39 |
MRA | 327 (71.9%) | 383 (78.8%) | 16.10 | 0.015 |
Digoxin | 20 (4.4%) | 43 (8.8%) | 18.00 | 0.009 |
Aspirin | 426 (93.6%) | 450 (92.6%) | 4.10 | 0.61 |
