Figure 1
From: Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells
Absence of Ahr in T cells does not Influence Baseline Behavior. (A) Relative quantity of Ahr expression from in vitro skewed Th17 cells in Ahr KO and Ahr competent cells was determined by qPCR (n = 8 or 13/group). T test (p = < 0.0001). (B) Relative quantity of Cyp1b1 expression from Ahr KO and competent cells skewed in vitro to become Th17s and treated with an Ahr agonist (I3S), antagonist (CH223191), or control media (DMSO) (n = 3–4/group). Combined N = 2. Two-way ANOVA (DMSO to I3S: p = 0.0019; I3s to CH223191: p = 0.0016, interaction statistics in Supplemental Table 1). (C) Baseline behavioral comparisons between Ahr KO and littermate controls (n = 13–14/group). T tests. Male mice.
