Figure 2
From: Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells
Unpredictable Chronic Stress (UCS) Drives Expansion of Th17s in the Lamina Propria in an Ahr Independent Manner. (A) Schematic representing timeline for UCS in mice. (B) Measures of learned helplessness and anxiety-like behaviors between Ahr KO and littermate controls (n = 13–14/group). T tests, male mice. (C) Kullback–Leibler divergence heatmap and (D) PCA plot of DeepLabCut analyzed behaviors between groups (n = 13–14/group). A single representative experiment is shown (N = 2). (E) Number of CD4 + ROR\(\gamma\)t + cells in various immune tissues between stressed and naïve Ahr KO and littermate controls (n = 5–7/group). Two-way ANOVA (Peyer’s Patches: p = 0.0026, Lamina Propria: p = 0.0359, Inguinal LN: p = 0.0440), N = 1, male mice. LN = lymphnode.
