Table 3 Multivariate analysis of risk factors for treatment failure in patients with Acinetobacter baumannii bacteraemia, according to the appropriateness of empirical therapy.
Risk factors | Inappropriate empirical antibiotics (n = 179) | Appropriate empirical antibiotics (n = 125) | ||
|---|---|---|---|---|
aOR (95% CI) | P | aOR (95% CI) | P | |
Male | – | – | 2.36 (0.89–6.23) | 0.084 |
ICU stay at bacteraemia onset | – | – | 1.23 (0.36–4.25) | 0.746 |
Healthcare-associated infection | 5.14 (0.43–61.37) | 0.196 | – | – |
Site of infection | ||||
Primary bacteraemia | – | – | 1.50 (0.47–4.78) | 0.489 |
CRBSI | 2.35 (0.98–5.64) | 0.055 | – | – |
Pneumonia | – | – | 10.56 (2.68–41.57) | 0.001 |
Underlying medical condition | ||||
Charlson’s WIC ≥ 3 | – | – | 4.66 (1.07–20.36) | 0.041 |
Heart disease | 2.72 (0.66–11.31) | 0.168 | – | – |
Lung disease | – | – | 4.32 (0.65–28.67) | 0.130 |
Clinical severity | ||||
Severe sepsis or septic shock | 22.70 (9.48–54.39) | < 0.001 | 1.67 (0.60–4.66) | 0.330 |
Pitt score | 1.58 (1.36–1.83) | < 0.001 | 1.15 (0.94–1.41) | 0.169 |
Carbapenem resistance | 6.17 (1.13–33.75) | 0.036 | 4.15 (1.16–14.84) | 0.029 |
