Table 4 Multivariate analysis of risk factors for treatment failure in patients with Pseudomonas aeruginosa bacteraemia, according to the appropriateness of empirical therapy.
Risk factors | Inappropriate empirical antibiotics (n = 78) | Appropriate empirical antibiotics (n = 163) | ||
|---|---|---|---|---|
aOR (95% CI) | P | aOR (95% CI) | P | |
Male | – | – | 3.61 (1.23–10.65) | 0.020 |
ICU stay at bacteraemia onset | – | – | 1.32 (0.41–4.29) | 0.645 |
Hospital-acquired infection | 4.57 (1.34–15.54) | 0.015 | 2.88 (1.09–7.65) | 0.033 |
Site of infection | ||||
Primary bacteraemia | – | – | 2.79 (0.94–8.25) | 0.064 |
Pneumonia | 4.61 (0.68–31.20) | 0.117 | 3.82 (1.09–13.32) | 0.036 |
Urinary tract infection | – | – | 0.13 (0.02–0.79) | 0.027 |
Underlying medical condition | ||||
Malignancy | 2.09 (0.55–7.91) | 0.276 | 1.81 (0.66–4.96) | 0.251 |
Immunosuppressant use | 3.31 (0.78–14.11) | 0.105 | 1.58 (0.54–4.63) | 0.406 |
Clinical severity | ||||
Severe sepsis or septic shock | 5.43 (1.42–20.76) | 0.013 | 10.33 (3.56–29.94) | < 0.001 |
Pitt score | 1.59 (1.21–2.10) | 0.001 | 1.59 (1.27–1.99) | < 0.001 |
Carbapenem resistance | 0.91 (0.27–3.03) | 0.879 | 1.76 (0.45–6.87) | 0.418 |
