Table 3 Examples of studied and predicted EF hand proteins in bacteria.
Protein name/accession number | Organism | Function | Structural properties | Predicted Subcellular location | Kd for Ca2+ | References |
|---|---|---|---|---|---|---|
EfhP AAG07494.1 | P. aeruginosa | Regulates Ca2+ induced virulence and intracellular Ca2+ homeostasis | 2 EF hands | Periplasmic | 13.7 µM | This study,17 |
CasA AF288533 | Rhizobium etli | Mediates Ca2+ dependent symbiosis with leguminous host | 3 EF hands | Secreted | NA | |
CabD Q9F377_STRCO | Streptomyces coelicolor | Affects formation of aerial mycelium | 2 EF hands | Cytoplasmic | NA | |
CAMLP NP_215727 | M. tuberculosis | Activates NAD kinase and PDE upon Ca2+ binding | 1 EF hand | Cytoplasmic | NA | |
CAMLP AY319523.1 | M. smegmatis | Activates PDE | 1 EF hand | Cytoplasmic | NA | |
CALP YP_004243569 | B. subtilis | Activates PDE in Ca2+ dependent manner | NA | Cytoplasmic | NA | |
YtfA A0A6I4DFL7 | B. subtilis | Activates Ca2+ dependent proteins required for sporulation | 1 EF hand | Membrane | NA | |
CLP | Bordetella pertussis | Regulates pathogenesis by stimulating adenylate cyclase in Ca2+ dependent manner | NA | Secreted | NA | |
SdrD SDRD_STAA8 | Staphylococcus aureus | Promotes adhesion to host surface and resistance | 5 EF hands | Anchored to cell wall | 16 nM–111 µM |
