Figure 1
From: Pyramidal cell axon initial segment in Alzheimer´s disease
taken from brain sections of the temporal neocortex from an AD patient (IF8, A−D) and a non-demented human case (AB1, E−H), showing the distribution of neurons with hyperphosphorylated tau revealed by DAB immunostaining with AT8 antibodies (B and F) in different cortical layers identified by NeuN immunostaining of adjacent sections (A and E, respectively).Squared areas in B, C, F and G are shown at higher magnification in C, D, G and H, respectively. Arrowheads indicate AT8-positive neurons. Scale bar shown in H indicates 106 µm in A, B, E and F, 47 µm in C and G and 21 µm in D and H. Adobe Photoshop CS4 software was used to compose figures.
Photomicrographs
