Table 1 Summary of clinical data and neurologic diagnosis according to Braak and Braak criteria40, defined by different stages (from I to VI), and according to CERAD criteria (Consortium to Establish a Registry for Alzheimer’s Disease)41, which use a semiquantitative score of the density of neuritic plaques in the most severely affected region of the isocortex (A = mild presence of plaques, B = moderate presence of plaques, C = severe presence of plaques).
From: Pyramidal cell axon initial segment in Alzheimer´s disease
Cases | Age (years) | Gender | Postmortem delay (hours) | Neurologic diagnosis | Additional Neurological diagnosis | Cause of death |
|---|---|---|---|---|---|---|
IF6 | 85 | Male | 2 | AD III-A | – | – |
IF8 | 91 | Male | 2.5 | AD III-A | AGD stage III, neuronal ballooning | – |
IF13 | 75 | Male | 2 | AD III-B | AGD stage III | Lymphoproliferative disorder |
AB1 | 45 | Male | < 1 | – | – | Pleural mesothelioma |
AB6 | 92 | Female | 4 | III-A | Aging-related tau astrogliopathy | – |
IF1 | 80 | Female | 2 | AD IV-B | – | – |
IF5 | 80 | Female | 3 | AD III, – | TDP43 | – |
IF7 | 88 | Female | 2 | AD III, – | AGD | – |
AB5 | 59 | Male | 4 | III, – | – | – |
Vk11 | 87 | Female | 1.5 | AD III/IV—A | Small Vessel Disease | Respiratory infection |
Vk16 | 88 | Female | 2 | AD VI-C | Vascular alterations; LBD; HS | – |
Vk22 | 86 | Female | 2 | AD V | Amyloid angiopathy. Small Vessel Disease. Vessel atheromatosis | – |
VK27 | 95 | Female | 4 | AD V-B | LBD (amygdala) Type II Amyloid angiopathy | – |
Bcn2 | 82 | Female | 2 | AD V-C | α Syn (amygdala); HS | – |
Bcn3 | 81 | Female | 5.30 | AD V-C | TDP43 | – |
Bcn5 | 83 | Female | 4 | AD V/VI-C | Microinfarctions | – |
Bcn8 | 64 | Female | < 6 | AD VI-C | Amyloid angiopathy | – |
Bcn12 | 74 | Female | 3.30 | AD VI-C | Small Vessel Disease | – |
