Figure 5 | Scientific Reports

Figure 5

From: Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division

Figure 5

Cholesterol staining changes in PGCC upon LCL521 treatment. (A) Uncropped 20X images of parental cells stained with filipin III to visualize cholesterol after 48 h of indicated treatment. (B) 20X images of PGCC after the same protocol as (A). Yellow arrows indicate the perinuclear accumulation of cholesterol. (C) Quantification of at least three images per experiment over three experiments; vehicle treated PGCC n = 86 and LCL521 treated PGCC n = 73. **** p < 0.0001.

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