Table 1 Demographics and clinical characteristics of patients.

From: Extended infusion of piperacillin–tazobactam versus intermittent infusion in critically ill egyptian patients: a cost-effectiveness study

Characteristic

Intermittent (n = 27)

Extended (n = 26)

P value

Age (years)a

(Mean ± SD)

53.0 ± 17.61

57.8 ± 15.35

0.291

Sex, n (%)b

Male

14 (52%)

12 (46%)

0.678

Female

13 (48%)

14 (54%)

 

Mechanical Ventilation, n (%)b

19 (70%)

18 (69%)

0.928

APACHE II score (Median & IQR)c

11 (7.0–16.0)

8.5 (6.75–13.25)

0.275

Diabetes, n (%)b

11 (41%)

10 (38%)

0.865

Smoking, n (%)d

4 (15%)

1 (4%)

0.172

SCRa (Mean ± SD)

1.8 ± 0.93

1.1 ± 0.54

0.002

ALTa (Mean ± SD)

90.0 ± 191.04

74.7 ± 117.13

0.727

ASTa (Mean ± SD)

127.0 ± 256.34

58.4 ± 61.10

0.183

WBCs (*109 /L)a(Mean ± SD)

11.9 ± 5.81

11.3 ± 8.6

0.784

Temperature (oC ) a (Mean ± SD)

37.4 ± 0.78

37.2 ± 0.46

0.475

Positive cultures, n (%)b

12 (44.4%)

15 (57.7%)

0.414

Infection source, n (%)b,d

Respiratory tract

18 (66.7)

15 (57.6)

0.577

Wound

1 (3.7)

0 (0)

1.000

Urinary tract

2 (7.4)

4 (15.3)

0.420

Skin or soft tissue

0 (0)

2 (7.6)

0.236

Abdominal

0 (0)

1 (3.8)

0.491

Blood

4 (14.8)

4 (15.3)

1.000

Respiratory and blood

2 (7.4)

0 (0)

0.491

Vasopressors

16 (59.3)

10 (38.5)

0.130

Concomitant antibiotics, n (%)b,d

Vancomycin

14 (51.9)

4 (15.4)

0.005

Aminoglycosides

1 (3.7)

2 (7.7)

0.530

Clindamycin

1 (3.7)

2 (7.7)

0.530

Quinolones

12 (44.4)

15 (57.7)

0.335

Linezolid

0 (0)

2 (7.7)

0.142

  1. All patients are Egyptians. Data are reported as mean ± SD, number (%) or median (interquartile range), ALT Alanine Transaminase, AST Aspartate Aminotransferase, APACHE II Acute Physiology and Chronic Health Evaluation, SCR Serum Creatinine, WBCs White blood cells. Results were compared using aIndependent T-test, bchi-square test, cMann-Whitney U test, dFisher’s exact Test. P-value ≤ 0.05 is considered statistically significant.
  2. Significant P-values are in bold.