Table 5 Association of baseline factor level with 90-day change in 6-min walk distance (6MWD).

From: Plasma metabolites associated with functional and clinical outcomes in heart failure with reduced ejection fraction with and without type 2 diabetes

Factor

Overall estimate

P-value

Diabetic estimate

P-value

Non-diabetic estimate

P-value

Basic

1

4.254

0.750

7.042

0.702

1.477

0.942

2

− 15.290

0.099

− 16.155

0.209

− 13.567

0.351

4

− 3.531

0.831

− 6.660

0.760

− 0.283

0.992

5

15.407

0.103

7.786

0.551

31.156

0.032

7

− 1.248

0.892

6.821

0.594

− 14.656

0.321

8

− 15.685

0.119

− 7.370

0.597

− 32.856

0.033

11

− 26.923

0.004

− 30.528

0.017

− 25.749

0.072

13

− 25.391

0.032

− 22.506

0.153

− 28.126

0.154

Fulla

11

− 25.278

0.010

− 24.562

0.088

− 31.830

0.060

13

− 28.932

0.032

− 28.366

0.114

− 33.403

0.173

  1. Significant values are in bold.
  2. aModel: change in 6 min walk dist (D90 − baseline) ~ baseline factor + baseline 6 min walk dist + age + sex + race + randomization drug + BMI + baseline creatinine + SBP + baseline NT-proBNP + liver function tests + diabetes (overall only).
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