Figure 4 | Scientific Reports

Figure 4

From: Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter

Figure 4Figure 4

Integrative identification of potential mechanisms and key regulators involved in PM-induced skin diseases. (a) Simplified pathway relevant to PM-induced skin diseases (refer to public data-based network in Fig. 2). Genes highlighted in orange, violet, and green, respectively, indicate atopic dermatitis-associated, allergic contact dermatitis-associated, and eczema-associated. Descriptions of the schematic symbols are located to the left of the figure. (b) Overlap with fold-change values from our RNA-seq experiments to identify activation/inhibition patterns. Criteria for differential expression is p < 0.05 and |fold-change| > 2. Upregulated genes are highlighted in pink. Schematic legends are located to the left of the figure. (c) Validation of mRNA expression profiles of key regulators using qRT-PCR. The upregulation of MMP9, MMP1, S100A8, S1009, and PLAU was confirmed. IL6 did not show significant fold-changes in RNA-seq, but changes in RNA expression levels were confirmed by qRT-PCR.

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