Table 2 Profiles of the 32 genes identified through literature-based analysis and used to construct the significant signaling networks.

From: Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter

Gene name

Description

Centrality with functional classes

Centrality with cell processes

Betweenness

Degree

Betweenness

Degree

IL6

Interleukin 6

0.32786356

60

0.2606371

53

MMP9

Matrix metallopeptidase 9

0.14008759

43

0.08874194

42

PRKCA

Protein kinase C alpha

0.10249921

23

0.06604883

26

SERPINE1

Serpin family E member 1

0.0940557

31

0.03619284

29

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

0.07616875

34

0.05170048

31

PLAU

Plasminogen activator, urokinase

0.0535497

33

0.03590776

31

MMP1

Matrix metallopeptidase 1

0.04540664

18

0.06081282

24

EGR1

Early growth response 1

0.02858809

23

0.01102559

27

BIRC3

Baculoviral IAP repeat containing 3

0.01057176

4

0.04105898

6

NDRG1

N-myc downstream regulated 1

0.01028651

3

0.00756754

11

AKAP13

A-kinase anchoring protein 13

0.00621003

4

0.00486438

3

S100A8

S100 calcium binding protein A8

0.00602783

19

0.01403312

23

IGFBP3

Insulin like growth factor binding protein 3

0.00470338

12

0.00350003

14

S100A9

S100 calcium binding protein A9

0.00295347

13

0.01168803

18

ABCA1

ATP binding cassette subfamily A member 1

0.00271365

7

4.68E−04

6

SOX9

SRY-box 9

0.00195307

9

0.00333093

13

CXCL1

C-X-C motif chemokine ligand 1

0.00167127

8

0.01085271

17

ANGPTL4

Angiopoietin like 4

7.66E−04

3

3.80E−04

6

SH3KBP1

SH3 domain containing kinase binding protein 1

3.22E−04

2

0

1

STK4

Serine/threonine kinase 4

3.22E−04

2

7.43E−04

5

MAP3K20

Mitogen-activated protein kinase kinase kinase 20

2.42E−04

2

2.83E−04

2

GBP1

Guanylate binding protein 1

2.25E−04

2

0

1

THBS2

Thrombospondin 2

1.93E−04

6

4.16E−04

7

AKAP12

A-kinase anchoring protein 12

0

2

0

3

CFB

Complement factor B

0

2

0

1

GREM1

Gremlin 1, DAN family BMP antagonist

0

1

0.00179531

7

IFI16

Interferon gamma inducible protein 16

0

2

0.00127899

5

ITGA2

Integrin subunit alpha 2

0

3

2.46E−04

4

MT1F

Metallothionein 1F

0

1

0

2

MYH10

Myosin heavy chain 10

0

1

0

2

SERPINB2

Serpin family B member 2

0

4

1.47E−04

7

TFPI

Tissue factor pathway inhibitor

0

2

3.20E−04

6

Back to article page